PDRN (Poly Deoxy Ribo Nucleotide) stimulates and increases the
metabolic activity of cells in
the skin called fibroblasts so that to
regenerate key components of the
skin such as collagen,
glycosaminoglycans and glycoproteins.
PDRN activates tired aged and damaged cells to act younger and get to
work again.
It also acts mechanically as a scaffolding for
cells and the extracellular matrix to grow –
they have a 3-dimensional
structure where fibroblasts can use to produce its regenerative effects.
Polydeoxyribonucleotide (PDRN) contains deoxyribonucleotide polymers
where 50 to 2000 base pairs are combined in a chain,
is known to
accelerate cell proliferation by activating A2 subtype
purinergic
receptor and salvage pathway.
PDRN helps the regeneration of skin and
tissue, it could also be used for
clinical treatment of diabetic foot
ulcers.
Since it helps the skin regeneration, it could be use after
laser treatment.
PDRN was indicated for tissue repair and treatment of
wound in
skin graft in 2008 by KFDA.
PDRN was first approved for
clinical use in Italy as a tissue repair stimulating agent.